A spleen can become enlarged for many reasons, including genetic diseases, William Katkov, MD, a gastroenterologist at Providence Saint John’s Health Center in Santa Monica, Calif., tells Yahoo Health. Here’s why that’s a problem: A person may feel better and resume their normal activities, but their enlarged spleen is more susceptible to rupturing and may no longer be protected by their ribcage, leaving it incredibly vulnerable to injury. “An enlarged spleen is at an increased risk for rupture or injury in the setting of normal trauma, like a football game, diving into a pool, or minor car accident,” Katkov says. While an enlarged spleen can be asymptomatic, Katkov says a person can feel uncomfortable or have a feeling of fullness in their upper abdomen on the left side. read more Disclaimer: Chances are that this post was requested by an advertiser.